Ischemia-free liver transplantation improves the prognosis of recipients using functionally marginal liver grafts.

ABSTRACT:

Background/aims

The shortage of donor liver hinders the development of liver transplantation. This study aimed to clarify the poor outcomes of functionally marginal liver grafts (FMLs) and provide evidence for the improvement of ischemia-free liver transplantation (IFLT) after FML transplantation.

Methods

Propensity score matching was used to control for confounding factors. The outcomes of the control group and FML group were compared to demonstrate the negative impact of FMLs on liver transplantation patients. We compared the clinical improvements of the different surgical types. To elucidate the underlying mechanism, we conducted bioinformatic analysis based on transcriptome and single-cell profiles.

Results

FMLs had a significantly greater hazard ratio (HR: 1.969,

SUBMITTER: Wang S 

PROVIDER: S-EPMC11261232 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature