Prescribers and patients drive maintenance therapy patterns in a community oncology practice: National guidelines versus the real-world experience.

ABSTRACT:

Objective

Previous studies have shown that first-line (1L) maintenance therapy (MT) with poly(ADP-ribose) polymerase inhibitors and/or bevacizumab improves outcomes among patients with advanced ovarian cancer (OC); however, these treatments are underutilized. This study aimed to provide a real-world understanding of MTs among patients with advanced OC who received 1L platinum-based chemotherapy (PBC).

Methods

A retrospective chart review using iKnowMed electronic health records to identify patients aged ≥18 years with advanced OC who initiated 1L PBC between January 1, 2018-December 31, 2020. Following 1L PBC, patients could have received MT or active surveillance (AS). Kaplan-Meier methods were used to estimate time to treatment discontinuation (TTD), real-world progression

SUBMITTER: Chase DM 

PROVIDER: S-EPMC11261288 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature