Identification of biomarkers related to tryptophan metabolism in osteoarthritis.

ABSTRACT:

Background

OA (osteoarthritis) is a common joint disease characterized by damage to the articular cartilage and affects the entire joint tissue, with its main manifestations being joint pain, stiffness, and limited movement.Currently,we know that OA is a complex process composed of inflammatory and metabolic factors.It is reported that the occurrence and development of OA is related to the change of tryptophan metabolism.Therefore, the study of tryptophan metabolism and OA related genes is hopeful to find a new therapeutic target for OA.

Methods

Differentially expressed genes (DEGs) in GSE55235 were gained via differential expression analysis (OA samples vs normal samples). The tryptophan metabolic related DEGs (TMR-DEGs) were obtained by overlapping tryptophan metabo

SUBMITTER: Yang J 

PROVIDER: S-EPMC11261530 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature