Light-Induced Transformation of Virus-Like Particles on TiO₂.

ABSTRACT: Titanium dioxide (TiO₂) shows significant potential as a self-cleaning material to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent virus transmission. This study provides insights into the impact of UV-A light on the photocatalytic inactivation of adsorbed SARS-CoV-2 virus-like particles (VLPs) on a TiO₂ surface at the molecular and atomic levels. X-ray photoelectron spectroscopy, combined with density functional theory calculations, reveals that spike proteins can adsorb on TiO₂ predominantly via their amine and amide functional groups in their amino acids blocks. We employ atomic force microscopy and grazing-incidence small-angle X-ray scattering (GISAXS) to investigate the molecular-scale morphological changes during t

SUBMITTER: Kohantorabi M 

PROVIDER: S-EPMC11261565 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature