Changes in mitochondrial distribution occur at the axon initial segment in association with neurodegeneration in Drosophila.

ABSTRACT: Changes in mitochondrial distribution are a feature of numerous age-related neurodegenerative diseases. In Drosophila, reducing the activity of Cdk5 causes a neurodegenerative phenotype and is known to affect several mitochondrial properties. Therefore, we investigated whether alterations of mitochondrial distribution are involved in Cdk5-associated neurodegeneration. We find that reducing Cdk5 activity does not alter the balance of mitochondrial localization to the somatodendritic versus axonal neuronal compartments of the mushroom body, the learning and memory center of the Drosophila brain. We do, however, observe changes in mitochondrial distribution at the axon initial segment (AIS), a neuronal compartment located in the proximal axon involved in neuronal polarization and action poten

SUBMITTER: Wodrich APK 

PROVIDER: S-EPMC11261633 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature