Effects of hydromorphone-based patient-controlled intravenous analgesia on postoperative hypoxaemia: a randomised controlled non-inferiority clinical trial.

ABSTRACT:

Objective

This study aimed to compare the effects of patient-controlled intravenous analgesia (PCIA) with and without low-basal infusion on postoperative hypoxaemia.

Design

A randomised parallel-group non-inferiority trial.

Setting

The trial was conducted at a grade-A tertiary hospital from December 2021 to August 2022.

Participants

160 adults undergoing gastrointestinal tumour surgery and receiving postoperative PCIA.

Interventions

Participants randomly received a low-basal (0.1 mg/hour of hydromorphone) or no-basal infusion PCIA for postoperative 48 hours.

Primary and secondary outcome measures

Primary outcome was area under curve (AUC) per hour for hypoxaemia, defined as pulse oxygen saturation (SpO₂) <95%. Secondary outcomes include

SUBMITTER: Ma Y 

PROVIDER: S-EPMC11261671 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature