Proteomic and phenotypic characteristics of memory-like natural killer cells for cancer immunotherapy.

ABSTRACT:

Background

Human and mouse natural killer (NK) cells have been shown to develop memory-like function after short-term exposure to the cocktail of IL-12/15/18 or to overnight co-culture with some tumor cell lines. The resulting cells retain enhanced lytic ability for up to 7 days as well as after cryopreservation, and memory-like NK cells (mlNK) have been shown to induce complete remissions in patients with hematological malignancies. No single phenotype has been described for mlNK and the physiological changes induced by the short-term cytokine or tumor-priming which are responsible for these enhanced functions have not been fully characterized. Here, we have generated mlNK by cytokine and tumor-priming to find commonalities to better define the nature of NK cell "memory" in vitro

SUBMITTER: Arellano-Ballestero H 

PROVIDER: S-EPMC11261707 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature