Plasmid genomic epidemiology of carbapenem-hydrolysing class D β-lactamase (CDHL)-producing Enterobacterales in Canada, 2010-2021.

ABSTRACT: Carbapenems are last-resort antibiotics for treatment of infections caused by multidrug-resistant Enterobacterales, but carbapenem resistance is a rising global threat due to the acquisition of carbapenemase genes. Oxacillinase-48 (bla _OXA-48)-type carbapenemases are increasing in abundance in Canada and elsewhere; these genes are frequently found on mobile genetic elements and are associated with specific transposons. This means that alongside clonal dissemination, bla _OXA-48-type genes can spread through plasmid-mediated horizontal gene transfer. We applied whole genome sequencing to characterize 249 bla _OXA-48-type-producing Enterobacterales isolates collected by the Canadian Nosocomial Infection Surveillance Program fr

SUBMITTER: Lerminiaux N 

PROVIDER: S-EPMC11261825 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature