Characterization of Aspergillus fumigatus secretome during sublethal infection of Galleria mellonella larvae.

ABSTRACT: Introduction. The fungal pathogen Aspergillus fumigatus can induce prolonged colonization of the lungs of susceptible patients, resulting in conditions such as allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis.Hypothesis. Analysis of the A. fumigatus secretome released during sub-lethal infection of G. mellonella larvae may give an insight into products released during prolonged human colonisation.Methodology. Galleria mellonella larvae were infected with A. fumigatus, and the metabolism of host carbohydrate and proteins and production of fungal virulence factors were analysed. Label-free qualitative proteomic analysis was performed to identify fungal proteins in larvae at 96 hours post-infection and also to

SUBMITTER: Curtis A 

PROVIDER: S-EPMC11261830 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature