Neuroprotective effects of MK-801 against cerebral ischemia reperfusion.

ABSTRACT:

Introduction

& Objective: Cerebral ischemia/reperfusion (I/R) injury, the second cause of death globally, involves increased NMDA receptor activity leading to neuronal damage due to excessive sodium and calcium ion entry. Therefore, targeting NMDA receptor may potentially reduce cell death induced by brain injury. Our study aimed to investigate the role of NMDA receptors in hippocampal neuronal activity induced by I/R.

Methods

In this study, Wistar rats were divided into four groups: sham, I/R, I/R + MK801, and I/R + NMDA. Cerebral I/R injury was induced by temporarily occluding the common and vertebral carotid arteries, followed by reperfusion. MK801 or NMDA was administered to the rats after a specific reperfusion time. Neuronal density and cell morphology in the hippocamp

SUBMITTER: Yaghoobi Z 

PROVIDER: S-EPMC11261850 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature