Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity.

ABSTRACT: The rational design of materials with cell-selective membrane activity is an effective strategy for the development of targeted molecular imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme-mediated molecular transformation followed by supramolecular assembly to form nanofibers in which cationic clusters are presented on a rigid β-sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self-assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramolecular nanomaterials with emergi

SUBMITTER: Yang S 

PROVIDER: S-EPMC11261884 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature