Estimating geographical spread of Streptococcus pneumoniae within Israel using genomic data.

ABSTRACT: Understanding how pathogens spread across geographical space is fundamental for control measures such as vaccination. Streptococcus pneumoniae (the pneumococcus) is a respiratory bacterium responsible for a large proportion of infectious disease morbidity and mortality globally. Even in the post-vaccination era, the rates of invasive pneumococcal disease (IPD) remain stable in most countries, including Israel. To understand the geographical spread of the pneumococcus in Israel, we analysed 1174 pneumococcal genomes from patients with IPD across multiple regions. We included the evolutionary distance between pairs of isolates inferred using whole-genome data within a relative risk (RR) ratio framework to capture the geographical structure of S. pneumoniae. While we could not f

SUBMITTER: Cheng HR 

PROVIDER: S-EPMC11261897 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature