Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.

ABSTRACT: A major challenge for human neuroimaging using functional MRI is the differentiation of neuronal excitation and inhibition which may induce positive and negative BOLD responses. Here we present an innovative multi-contrast laminar functional MRI technique that offers comprehensive and quantitative imaging of neurovascular (CBF, CBV, BOLD) and metabolic (CMRO₂) responses across cortical layers at 7 Tesla. This technique was first validated through a finger-tapping experiment, revealing 'double-peak' laminar activation patterns within the primary motor cortex. By employing a ring-shaped visual stimulus that elicited positive and negative BOLD responses, we further observed distinct neurovascular and metabolic responses across cortical layers and eccentricities in the primary visua

SUBMITTER: Shao X 

PROVIDER: S-EPMC11261924 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature