Association of white matter hyperintensities with BMD, incident fractures, and falls in the UK Biobank cohort.

ABSTRACT: Osteoporosis is the most common metabolic bone disease globally, which increases the healthcare service burden. Recent studies have linked higher white matter hyperintensities (WMH) to reduced BMD, increasing the risk of fractures and falls in older adults. However, limited evidence exists regarding the dose-response relationship between WMH and bone health in a larger and younger population. Our study aimed to examine the association of WMH volume with BMD, incident fractures and falls, focusing on dose-response relationship with varying levels of WMH volume. We included 26 410 participants from the UK Biobank. The association between WMH volume and BMD was analyzed using multiple linear regression. Cox regression models were used to estimate the hazard ratios of incident fractures and fa

SUBMITTER: Cai L 

PROVIDER: S-EPMC11262152 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature