Effects of d-alanine Intake on Amino Acid Metabolism and Kidney Function in Healthy Adults: A Multicenter, Randomized Pilot Study.

ABSTRACT:

Background

d-alanine administration prevented kidney damage in a murine acute kidney injury model. Further data are needed on the influence of d-alanine on kidney function in humans.

Objective

This study investigated the effects of d-alanine intake on amino acid metabolism and kidney function in healthy volunteers.

Methods

This multicenter pilot study randomly assigned individuals from the general Japanese population to receive 3 g or 6 g of d-alanine intake per day for 7 d in a 1:1 ratio. The primary endpoint was the mean change in plasma and urine d-alanine levels from baseline to 7 d after intake. The secondary endpoints were mean changes in kidney function and other clinical factors. Safety was assessed by evaluating adverse events and clinical parameters.

Resu

SUBMITTER: Oshima M 

PROVIDER: S-EPMC11262164 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature