Estimate the number of lives saved by a SARS-CoV-2 vaccination campaign in six states in the United States with a simple model.

ABSTRACT:

Objectives

Vaccination and the emergence of the highly transmissible Omicron variant changed the fate of the COVID-19 pandemic. It is very challenging to estimate the number of lives saved by vaccination given the multiple doses of vaccination, the time-varying nature of transmissibility, the waning of immunity, and the presence of immune evasion.

Methods

We established a S-S_V-E-I-T-D-R model to simulate the number of lives saved by vaccination in six states in the United States (U.S.) from March 5, 2020, to March 23, 2023. The cumulative number of deaths were estimated under three vaccination scenarios based on two assumptions. Additionally, immune evasion by the Omicron and loss of protection afforded by vaccination or infection were considered.

Results

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SUBMITTER: Yin Y 

PROVIDER: S-EPMC11262167 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature