Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer.

ABSTRACT: Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility for prostate cancer (PCa) screening. Using genome-wide association study (GWAS) summary statistics from 95,768 PCa-free men, we conducted a transcriptome-wide association study (TWAS) to examine impacts of genetically predicted gene expression on PSA. Analyses identified 41 statistically significant (p < 0.05/12,192 = 4.10 × 10^-6) associations in whole blood and 39 statistically significant (p < 0.05/13,844 = 3.61 × 10^-6) associations in prostate tissue, with 18 genes associated in both tissues. Cross-tissue analyses identified 155 statistically significantly (p < 0.05/22,249 = 2.25 × 10^-6) genes. Out of 173 unique PSA-associated genes across analyses, we repli

SUBMITTER: Chen DM 

PROVIDER: S-EPMC11262184 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature