Representation of rhythmic chunking in striatum of mice executing complex continuous movement sequences.

ABSTRACT: We used a step-wheel system to examine the activity of striatal projection neurons as mice practiced stepping on complexly arranged foothold pegs in this Ferris-wheel-like device to receive reward. Sets of dorsolateral striatal projection neurons were sensitive to specific parameters of repetitive motor coordination during the runs. They responded to combinations of the parameters of continuous movements (interval, phase, and repetition), forming "chunking responses"-some for combinations of these parameters across multiple body parts. Recordings in sensorimotor cortical areas exhibited notably fewer such responses but were documented for smaller neuron sets whose heterogeneity was significant. Striatal movement encoding via chunking responsivity could provide insight into neural strategie

SUBMITTER: Hirokane K 

PROVIDER: S-EPMC11262464 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature