Sequence of Morphological Changes Preceding Atrophy in Intermediate AMD Using Deep Learning.

ABSTRACT:

Purpose

Investigating the sequence of morphological changes preceding outer plexiform layer (OPL) subsidence, a marker preceding geographic atrophy, in intermediate AMD (iAMD) using high-precision artificial intelligence (AI) quantifications on optical coherence tomography imaging.

Methods

In this longitudinal observational study, individuals with bilateral iAMD participating in a multicenter clinical trial were screened for OPL subsidence and RPE and outer retinal atrophy. OPL subsidence was segmented on an A-scan basis in optical coherence tomography volumes, obtained 6-monthly with 36 months follow-up. AI-based quantification of photoreceptor (PR) and outer nuclear layer (ONL) thickness, drusen height and choroidal hypertransmission (HT) was performed. Changes were compar

SUBMITTER: Riedl S 

PROVIDER: S-EPMC11262471 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature