"I don't need any more unknowns hanging over my head": Views of patients with cancer on variants of uncertain significance and low/moderate risk results from genomic sequencing.

ABSTRACT:

Purpose

We sought to explore patient-reported utility of all types of cancer results from genomic sequencing (GS).

Methods

Qualitative study, using semi-structured interviews with patients who underwent GS within a trial. Thematic analysis employing constant comparison was used. Two coders coded transcripts, with use of a third coder to resolve conflicts.

Results

25 patients participated: female (22), >50 years (18), European (12), Ashkenazi Jewish (5), Middle Eastern (3), or other ethnicity (5), with breast cancer history (20). Patients' perceptions of the utility of cancer GS results hinged on whether they triggered clinical action. For example, when patients were enrolled into high-risk breast cancer surveillance programs for low/moderate risk breast cancer genes,

SUBMITTER: Shickh S 

PROVIDER: S-EPMC11262616 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature