Multi-omic analysis of bat versus human fibroblasts reveals altered central metabolism.

ABSTRACT: Bats have unique characteristics compared to other mammals, including increased longevity and higher resistance to cancer and infectious disease. While previous studies have analyzed the metabolic requirements for flight, it is still unclear how bat metabolism supports these unique features, and no study has integrated metabolomics, transcriptomics, and proteomics to characterize bat metabolism. In this work, we performed a multi-omics data analysis using a computational model of metabolic fluxes to identify fundamental differences in central metabolism between primary lung fibroblast cell lines from the black flying fox fruit bat (Pteropus alecto) and human. Bat cells showed higher expression levels of Complex I components of electron transport chain (ETC), but, remarkably, a lower

SUBMITTER: Jagannathan NS 

PROVIDER: S-EPMC11262796 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature