Firing rate adaptation affords place cell theta sweeps, phase precession, and procession.

ABSTRACT: Hippocampal place cells in freely moving rodents display both theta phase precession and procession, which is thought to play important roles in cognition, but the neural mechanism for producing theta phase shift remains largely unknown. Here, we show that firing rate adaptation within a continuous attractor neural network causes the neural activity bump to oscillate around the external input, resembling theta sweeps of decoded position during locomotion. These forward and backward sweeps naturally account for theta phase precession and procession of individual neurons, respectively. By tuning the adaptation strength, our model explains the difference between 'bimodal cells' showing interleaved phase precession and procession, and 'unimodal cells' in which phase precession predominates. Ou

SUBMITTER: Chu T 

PROVIDER: S-EPMC11262797 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature