MiRAGE: mining relationships for advanced generative evaluation in drug repositioning.

ABSTRACT:

Motivation

Drug repositioning, the identification of new therapeutic uses for existing drugs, is crucial for accelerating drug discovery and reducing development costs. Some methods rely on heterogeneous networks, which may not fully capture the complex relationships between drugs and diseases. However, integrating diverse biological data sources offers promise for discovering new drug-disease associations (DDAs). Previous evidence indicates that the combination of information would be conducive to the discovery of new DDAs. However, the challenge lies in effectively integrating different biological data sources to identify the most effective drugs for a certain disease based on drug-disease coupled mechanisms.

Results

In response to this challenge, we present MiRAGE, a nove

SUBMITTER: Hassanali Aragh A 

PROVIDER: S-EPMC11262809 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature