Precision probiotics supplement strategy in aging population based on gut microbiome composition.

ABSTRACT: With the increasing prevalence of age-related chronic diseases burdening healthcare systems, there is a pressing need for innovative management strategies. Our study focuses on the gut microbiota, essential for metabolic, nutritional, and immune functions, which undergoes significant changes with aging. These changes can impair intestinal function, leading to altered microbial diversity and composition that potentially influence health outcomes and disease progression. Using advanced metagenomic sequencing, we explore the potential of personalized probiotic supplements in 297 older adults by analyzing their gut microbiota. We identified distinctive Lactobacillus and Bifidobacterium signatures in the gut microbiota of older adults, revealing probiotic patterns associated with various popula

SUBMITTER: Chuang YF 

PROVIDER: S-EPMC11262831 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature