GABA-edited MEGA-PRESS at 3 T: Does a measured macromolecule background improve linear combination modeling?

ABSTRACT:

Purpose

The J-difference edited γ-aminobutyric acid (GABA) signal is contaminated by other co-edited signals-the largest of which originates from co-edited macromolecules (MMs)-and is consequently often reported as "GABA+." MM signals are broader and less well-characterized than the metabolites, and are commonly approximated using a Gaussian model parameterization. Experimentally measured MM signals are a consensus-recommended alternative to parameterized modeling; however, they are relatively under-studied in the context of edited MRS.

Methods

To address this limitation in the literature, we have acquired GABA-edited MEGA-PRESS data with pre-inversion to null metabolite signals in 13 healthy controls. An experimental MM basis function was derived from the mean across subjec

SUBMITTER: Davies-Jenkins CW 

PROVIDER: S-EPMC11262975 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature