Association between blood metabolites and basal cell carcinoma risk: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Circulating metabolites, which play a crucial role in our health, have been reported to be disordered in basal cell carcinoma (BCC). Despite these findings, evidence is still lacking to determine whether these metabolites directly promote or prevent BCC's progression. Therefore, our study aims to examine the potential effects of circulating metabolites on BCC progression.

Material and methods

We conducted a two-sample Mendelian randomization (MR) analysis using data from two separate genome-wide association studies (GWAS). The primary study included data for 123 blood metabolites from a GWAS with 25,000 Finnish individuals, while the secondary study had data for 249 blood metabolites from a GWAS with 114,000 UK Biobank participants.GWAS data for BCC were obtained

SUBMITTER: Wu B 

PROVIDER: S-EPMC11263015 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature