Causal role of immune cells in uveitis: Mendelian randomization study.

ABSTRACT:

Background

Uveitis, characterized by inflammation of the iris, ciliary body, and choroid, presents a significant global clinical challenge, contributing substantially to visual impairment. Risk factors include autoimmune diseases and immune cell dysfunctions, yet many remain unidentified. Immune cells, notably T cells, B cells, and monocytes, play pivotal roles in uveitis pathogenesis. While biologic agents show promise, comprehensive studies on immune cell types in ocular diseases are lacking. Genome-wide association studies (GWAS) and Mendelian randomization (MR) present promising avenues to elucidate genetic susceptibilities and causal relationships between immune cell traits and uveitis risk.

Methods

Two-sample MR analysis was used to evaluate the causal relationship bet

SUBMITTER: Wu J 

PROVIDER: S-EPMC11263026 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature