Genetically predicted metabolites mediate the causal associations between autoimmune thyroiditis and immune cells.

ABSTRACT:

Introduction

We aimed to comprehensively investigate the causal relationship between 731 immune cell traits and autoimmune thyroiditis (AIT) and to identify and quantify the role of 1400 metabolic traits as potential mediators in between.

Methods

Using summary-level data from genome-wide association studies (GWAS) we performed a two-sample bidirectional Mendelian randomization (MR) analysis of genetically predicted AIT and 731 immune cell traits. Furthermore, we used a two-step MR analysis to quantify the proportion of the total effects (that the immune cells exerted on the risk of AIT) mediated by potential metabolites.

Results

We identified 24 immune cell traits (with odds ratio (OR) ranging from 1.3166 6 to 0.6323) and 10 metabolic traits (with OR ranging from 1.79

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11263034 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature