Older age is associated with a distinct and marked reduction of functionality of both alloreactive CD4+ and CD8+ T cells.

ABSTRACT:

Introduction

Older recipient age is associated with a significant decreased risk for rejection after kidney transplantation which is incompletely understood.

Methods

In a longitudinal study, circulating alloreactive T cells were assessed of young (≤45 years) and older (≥55 years) stable kidney transplant recipients. Alloreactive T-cells were identified by CD137-expression and phenotype, cytokine producing and proliferative capacity, were evaluated using multiparameter flowcytometry.

Results

The results show that before transplantation frequencies of alloreactive CD4+ and CD8+ T-cells in older KT-recipients are significantly higher and shifted towards an effector memory-phenotype. However, the frequency of polyfunctional (≥2 pro-inflammatory cytokines) CD4+ T-cells was

SUBMITTER: Litjens NHR 

PROVIDER: S-EPMC11263037 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature