Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats.

ABSTRACT:

Introduction

Systemic lupus erythematosus (SLE) is a diverse autoimmune disease that arises from a combination of complex genetic factors and environmental influences. While circRNAs and miRNAs have recently been identified as promising biomarkers for disease diagnosis, their specific expression patterns, and clinical implications in SLE are not yet fully understood.

Aim of the work

The aim of the present study was to determine the role of a panel of noncoding-RNAs specifically circRNAs (circ-TubD1, circ-CDC27, and circ-Med14), along with miRNA (rno-miR-146a-5p) and mRNA (TRAF6), as novel minimally invasive diagnostic biomarkers for experimentally induced SLE. Additionally, the study involved an insilico bioinformatics analysis to explore potential pathways involved in the p

SUBMITTER: Azzam MA 

PROVIDER: S-EPMC11263041 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature