The atypical antipsychotics and sexual dysfunction: a pharmacovigilance-pharmacodynamic study.

ABSTRACT:

Background

Atypical antipsychotics (AAPs)-induced sexual dysfunction (SD) is a frequent issue in clinical practice, often underestimated by clinicians and not extensively researched. The current study aimed to quantify the strength of association between the use of different AAPs and SD using real-world data from the FDA Adverse Event Reporting System (FAERS), as well as investigate the receptor mechanisms that are involved.

Methods

Data from the FAERS database from the first quarter of 2004 to the third quarter of 2023 were queried through OpenVigil 2.1. Disproportionality analysis was estimated using the reporting odds ratio (ROR) and information component (IC) methods, and linear regression was used to investigate the relationship between ROR and receptor occupancy which

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC11263075 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature