How should we measure population-level inbreeding depression? Impacts of standing genetic associations between selfing rate and deleterious mutations.

ABSTRACT: Inbreeding depression (ID) is a major selective force during mating system evolution primarily contributed by highly to partially recessive deleterious mutations. Theories suggest that transient genetic association with fitness alleles can be important in affecting the evolution of alleles that modify the selfing rate during its sweep. Nevertheless, empirical tests often focus on the pre-existing genetic association between selfing rate and ID maintained under mutation-selection balance. Therefore, how this standing genetic association is affected by key factors and its impacts on the evolution of selfing remain unclear. I show that as the selection coefficient of deleterious mutations increases, the association between selfing rate and ID declines from positive to negative. These results

SUBMITTER: Xu K 

PROVIDER: S-EPMC11263115 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature