Gut Microbiome and Atherosclerosis: A Mendelian Randomization Study.

ABSTRACT:

Background

According to recent studies, atherosclerosis and gut microbiota are related. Nevertheless, it has been discovered that the gut microbiota varies across studies, with its function still being debated, and such relationships not proven to be causal. Thus, our study aimed to identify the key gut microbiota taxa (GM taxa) at different taxonomic levels, namely, the phylum, class, order, family, and genus, to investigate any potential causal links to atherosclerosis.

Methods

We employed summary data from the MiBioGen consortium on the gut microbiota to conduct a sophisticated two-sample Mendelian randomization (MR) analysis. Pertinent information regarding atherosclerosis statistics was acquired from the FinnGen Consortium R8 publication. To assess causality, the utiliz

SUBMITTER: Li Y 

PROVIDER: S-EPMC11263158 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature