Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study.

ABSTRACT:

Purpose

To investigate the genetic correlation and causal links between sleep traits (including sleep duration, chronotype, and insomnia) and myopia.

Methods

Summary data on three sleep traits (sleep duration, chronotype and insomnia) and myopia from FinnGen (n = 214,211) and UK Biobank (n = 460,536) were analyzed using linkage disequilibrium score regression (LD Score), univariable and multivariable mendelian randomization (MR) experiments and Causal Analysis Using Summary Effect (CAUSE) estimation.

Results

LD Score regression detected candidate genetic correlation between sleep traits and myopia, such as sleep duration, chronotype (Genetic Correlation Z-score >10.00, h2_observed_p < 0.005, Lambda GC > 1.05, p > 0.05). Univariable MR analyses ind

SUBMITTER: Zhu G 

PROVIDER: S-EPMC11263174 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature