Molecular epidemiology and genomic features of Bordetella parapertussis in Shanghai, China, 2017-2022.

ABSTRACT:

Background

Pertussis is a highly contagious respiratory illness mainly caused by Bordetella pertussis (BP). Bordetella parapertussis (BPP) can induce symptoms compatible with pertussis, but has been underdiagnosed and underreported. The current pertussis vaccines offer low protection against BPP. Herein, we aim to reveal the epidemiology and genomic evolution of BPP in Shanghai, China.

Methods

Children diagnosed with BPP infection from January 2017 to December 2022 in Shanghai, China were enrolled. We performed antimicrobial susceptibility testing (AST), multiple locus variable-number tandem repeat analysis (MLVA), and whole genome sequencing (WGS) analysis. A total of 260 international BPP genomes were chosen for comparison to investigate the genomic diversity

SUBMITTER: Fu P 

PROVIDER: S-EPMC11263204 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature