Anthropometric traits and risk of multiple myeloma: differences by race, sex and diagnostic clinical features.

ABSTRACT:

Background

Obesity is an established modifiable risk factor for multiple myeloma (MM). However, associations of obesity and MM risk in Black populations, for whom obesity and MM are more common, is less clear.

Methods

Using participants enrolled in the Integrative Molecular And Genetic Epidemiology study, we evaluated the association of anthropometric traits with MM risk overall, stratified by race and sex. Among cases, we assessed the association of BMI with the presence of myeloma-defining events.

Results

We observed an 18% increase in MM risk for every 5 kg/m² increase in usual adult BMI. Participants with severe obesity (BMI ≥ 40 kg/m²) had the highest risk compared to those with a normal usual adult BMI (18.5-24.9 kg/m²; OR = 1.87

SUBMITTER: Arnold KD 

PROVIDER: S-EPMC11263363 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature