Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence.

ABSTRACT: Environmental and lifestyle factors, including air pollution, impaired diet, and low physical activity, have been associated with cardiometabolic risk factors in childhood and adolescence. However, environmental and lifestyle exposures do not exert their physiological effects in isolation. This study investigated associations between an exposome score to measure the impact of multiple exposures, including diet, physical activity, sleep duration, air pollution, and socioeconomic status, and serum metabolites measured using LC-MS and NMR, compared to the individual components of the score. A general population of 504 children aged 6-9 years at baseline was followed up for eight years. Data were analysed with linear mixed-effects models using the R software. The exposome score was associated

SUBMITTER: Healy DR 

PROVIDER: S-EPMC11263428 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature