Multi-omics data analysis reveals the complex roles of age in differentiated thyroid cancer.

ABSTRACT:

Aims

Age is a major risk factor for differentiated thyroid cancer (DTC); however, the mechanisms underlying aging-regulated progression of DTC remains unclear.

Methods

Based on multi-omics data (transcriptional files, somatic mutation files, methylation files) derived from the TCGA database, we comprehensively investigated the genomic and biological features associated with aging in patients with DTC.

Results

We confirmed that age was an independent risk factor for overall survival and progression-free survival of patients with DTC, and confirmed that 55 years of age (adopted in the 8th AJCC staging system) is an appropriate cutoff for patients with DTC rather than 45 years (adopted in the 7th AJCC staging system). Using 55 years as the cutoff, we demonstrated DNA met

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11263663 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature