Asthma and risk of adverse pregnancy outcomes: A Mendelian randomization study.

ABSTRACT:

Background

Multiple empirical investigations have indicated a connection between asthma and adverse pregnancy outcomes (APOs). Nevertheless, the effects of asthma on APOs remain uncertain.

Methods

We performed bi-directional Univariable Mendelian randomization (UVMR) analyses using combined information obtained from genome-wide association studies (GWAS) data that is publicly accessible. The principal approach used to analyze the causal association between asthma or age when diagnosed and APOs was the inverse variance weighted (IVW) method. The two types of data regarding exposure originate from the IEU Open GWAS project, which includes 56,167 and 47,222 European asthma patients, respectively. The data of four APOs were acquired via the GWAS dataset of the FinnGen collaborat

SUBMITTER: Han X 

PROVIDER: S-EPMC11263667 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature