Enhancing radiation-resistance and peroxidase-like activity of single-atom copper nanozyme via local coordination manipulation.

ABSTRACT: The inactivation of natural enzymes by radiation poses a great challenge to their applications for radiotherapy. Single-atom nanozymes (SAzymes) with high structural stability under such extreme conditions become a promising candidate for replacing natural enzymes to shrink tumors. Here, we report a CuN₃-centered SAzyme (CuN₃-SAzyme) that exhibits higher peroxidase-like catalytic activity than a CuN₄-centered counterpart, by locally regulating the coordination environment of single copper sites. Density functional theory calculations reveal that the CuN₃ active moiety confers optimal H₂O₂ adsorption and dissociation properties, thus contributing to high enzymatic activity of CuN₃-SAzyme. The introduction of X-ray

SUBMITTER: Wu J 

PROVIDER: S-EPMC11263674 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature