Mediodorsal thalamus and ventral pallidum contribute to subcortical regulation of the default mode network.

ABSTRACT: Humans and other animals readily transition from externally to internally focused attention, and these transitions are accompanied by activation of the default mode network (DMN). The DMN was considered a cortical network, yet recent evidence suggests subcortical structures are also involved. We investigated the role of ventral pallidum (VP) and mediodorsal thalamus (MD) in DMN regulation in tree shrew, a close relative of primates. Electrophysiology and deep learning-based classification of behavioral states revealed gamma oscillations in VP and MD coordinated with gamma in anterior cingulate (AC) cortex during DMN states. Cross-frequency coupling between gamma and delta oscillations was higher during DMN than other behaviors, underscoring the engagement of MD, VP and AC. Our findings hig

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC11263694 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature