Impact of intensity-modulated proton therapy in reducing radiation-induced lymphopenia in glioma patients.

ABSTRACT:

Background

Current standard management in adult grades 2-4 gliomas includes maximal safe resection followed by adjuvant radiotherapy (RT) and chemotherapy. Radiation-induced lymphopenia (RIL) has been shown to possibly affect treatment outcomes adversely. Proton beam therapy (PBT) may reduce the volume of the normal brain receiving moderate radiation doses, and consequently RIL. Our aim was to evaluate the incidence and severity of RIL during proton beam therapy (PBT).

Methods

We identified patients with grades 2-4 glioma treated with PBT at our center between January 2019 and December 2021. We evaluated the incidence and severity of RIL from weekly complete blood count (CBC) data collected during PBT and compared it to the patients who were treated with photon-based RT (XRT

SUBMITTER: Das A 

PROVIDER: S-EPMC11263926 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature