Induction of periodontal ligament-derived mesenchymal stromal cell-like cells from human induced pluripotent stem cells.

ABSTRACT:

Introduction

Periodontal disease is a common oral infection which affects the tooth-supportive tissues directly. Considering the limitation of present regenerative treatments for severe periodontal cases, cytotherapies have been gradually introduced. Human periodontal ligament-derived mesenchymal stromal cells (hPDLMSCs), while identified as one of the promising cell sources for periodontal regenerative therapy, still hold some problems in the clinical application especially their limited life span. To solve the problems, human induced pluripotent stem cells (hiPSCs) are taken into consideration as a robust supply for hPDLMSCs.

Methods

The induction of hPDLMSCs was performed based on the generation of neural crest-like cells (NCLCs) from hiPSCs. Fibronectin and laminin were

SUBMITTER: Wang J 

PROVIDER: S-EPMC11263952 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature