Risankizumab for Ulcerative Colitis: Two Randomized Clinical Trials.

ABSTRACT:

Importance

The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit of IL-23) for the treatment of ulcerative colitis are unknown.

Objective

To evaluate the efficacy and safety of risankizumab when administered as an induction and a maintenance therapy for patients with ulcerative colitis.

Design, setting, and participants

Two phase 3 randomized clinical trials were conducted. The induction trial was conducted at 261 clinical centers (in 41 countries) and enrolled 977 patients from November 5, 2020, to August 4, 2022 (final follow-up on May 16, 2023). The maintenance trial was conducted at 238 clinical centers (in 37 countries) and enrolled 754 patients from August 28, 2018, to March 30, 2022 (final follow-up on April 11, 20

SUBMITTER: Louis E 

PROVIDER: S-EPMC11264075 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature