Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish.

ABSTRACT: Bone matrix formation and mineralization are two closely related, yet separated processes. Matrix formation occurs first, mineralization is a second step strictly dependent on the dietary intake of calcium and phosphorus (P). However, mineralization is commonly used as diagnostic parameter for bone-related diseases. In this context, bone loss, often characterized as a condition with reduced bone mineral density, represents a major burden for human health, for which increased dietary mineral intake is generally recommended. Using a counterintuitive approach, we use a low-P diet followed by a sufficient-P intake to increase bone volume. We show in zebrafish by histology, qPCR, micro-CT, and enzyme histochemistry that a two-months period of reduced dietary P intake stimulates extensive format

SUBMITTER: Cotti S 

PROVIDER: S-EPMC11264301 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature