Antimicrobial susceptibility in Clostridioides difficile varies according to European region and isolate source.

ABSTRACT:

Objectives

Clostridioides difficile epidemiology is evolving with country-associated emerging and resistant ribotypes (RT). Antimicrobial susceptibility testing of C. difficile isolated from clinical and animal samples collected across Europe in 2018 was performed to provide antimicrobial resistance data and according to C. difficile RTs and source.

Methods

Samples were cultured for C. difficile and isolates PCR ribotyped. Metronidazole, vancomycin, fidaxomicin, moxifloxacin, clindamycin, imipenem, tigecycline, linezolid, rifampicin and meropenem minimum inhibitory concentrations (MICs) for 280 clinical and 126 animal isolates were determined by Wilkins-Chalgren agar dilution.

Results

Fidaxomicin was the most active antimicrobial (all isola

SUBMITTER: Freeman J 

PROVIDER: S-EPMC11264405 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature