Genetic distance and ancestry proportion modify the association between maternal genetic risk score of type 2 diabetes and fetal growth.

ABSTRACT:

Background

Maternal genetic risk of type 2 diabetes (T2D) has been associated with fetal growth, but the influence of genetic ancestry is not yet fully understood. We aimed to investigate the influence of genetic distance (GD) and genetic ancestry proportion (GAP) on the association of maternal genetic risk score of T2D (GRS_T2D) with fetal weight and birthweight.

Methods

Multi-ancestral pregnant women (n = 1,837) from the NICHD Fetal Growth Studies - Singletons cohort were included in the current analyses. Fetal weight (in grams, g) was estimated from ultrasound measurements of fetal biometry, and birthweight (g) was measured at delivery. GRS_T2D was calculated using T2D-associated variants identified in the latest trans-ancestral genome-wide association

SUBMITTER: Habtewold TD 

PROVIDER: S-EPMC11264503 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature