Tissue and cellular tropism of <i>Eptesicus fuscus gammaherpesvirus</i> in big brown bats, potential role of pulmonary intravascular macrophages.

ABSTRACT: Gammaherpesviruses (γHVs) are recognized as important pathogens in humans but their relationship with other animal hosts, especially wildlife species, is less well characterized. Our objectives were to examine natural Eptesicus fuscus gammaherpesvirus (EfHV) infections in their host, the big brown bat (Eptesicus fuscus), and determine whether infection is associated with disease. In tissue samples from 132 individual big brown bats, EfHV DNA was detected by polymerase chain reaction in 41 bats. Tissues from 59 of these cases, including 17 from bats with detectable EfHV genomes, were analyzed. An EfHV isolate was obtained from one of the cases, and electron micrographs and whole genome sequencing were used to confirm that this was a unique isolate of EfHV. Although several bat

SUBMITTER: Perdrizet UG 

PROVIDER: S-EPMC11264566 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature