Blood lipid profiles as a prognostic biomarker in idiopathic pulmonary fibrosis.

ABSTRACT:

Background

Dysregulation of lipid metabolism is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, the association between the blood lipid profiles and the prognosis of IPF is not well defined. We aimed to identify the impacts of lipid profiles on prognosis in patients with IPF.

Methods

Clinical data of 371 patients with IPF (145 and 226 in the derivation and validation cohorts, respectively), including serum lipid profiles (total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein A-I [Apo A-I], and apolipoprotein B), were retrospectively collected. The association with mortality was analyzed using the Cox proportional hazard model.

Results

In the derivation cohort, the mean

SUBMITTER: Oh JH 

PROVIDER: S-EPMC11264581 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature