Comparison of the full-length sequence and sub-regions of 16S rRNA gene for skin microbiome profiling.

ABSTRACT: The skin microbiome plays a pivotal role in human health by providing protective and functional benefits. Furthermore, its inherent stability and individual specificity present novel forensic applications. These aspects have sparked considerable research enthusiasm among scholars across various fields. However, the selection of specific 16S rRNA hypervariable regions for skin microbiome studies is not standardized and should be validated through extensive research tailored to different research objectives and targeted bacterial taxa. Notably, third-generation sequencing (TGS) technology leverages the full discriminatory power of the 16S gene and enables more detailed and accurate microbial community analyses. Here, we conducted full-length 16S sequencing of 141 skin microbiota samples from

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11264597 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature